Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » Growth Factors-TGF » TGFB2, Recombinant, Human (Transforming Growth Factor beta-2, TGF-beta-2, BSC-1 Cell Growth Inhibitor, Cetermin, Glioblastoma-derived T-cell Suppressor Factor, G-TSF, Polyergin, MGC116892)

TGFB2, Recombinant, Human (Transforming Growth Factor beta-2, TGF-beta-2, BSC-1 Cell
Growth Inhibitor, Cetermin, Glioblastoma-derived T-cell Suppressor Factor, G-TSF,
Polyergin, MGC116892)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-beta2 is a 25kD protein composed of two identical 112aa polypeptide chains linked by a single disulfide bond.
Catalog #149586
SourceRecombinant protein corresponding to human TGFbeta2, expressed in A293 cells.
Biological ActivityDetermined by its ability to inhibit mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be 0.2ng/ml
Specific Activity5x10e6units/mg
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceA293 cells
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links