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You are here:Home » Growth Factors, Cytokines » Growth Factors-FGF » FGF23, Recombinant, Human (Fibroblast Growth Factor 23, FGF-23, Phosphatonin, Tumor-derived Hypophosphatemia-inducing Factor, HYPF, UNQ3027/PRO9828, ADHR, HPDR2, PHPTC)

FGF23, Recombinant, Human (Fibroblast Growth Factor 23, FGF-23, Phosphatonin,
Tumor-derived Hypophosphatemia-inducing Factor, HYPF, UNQ3027/PRO9828, ADHR, HPDR2, PHPTC)

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Specifications

The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant human FGF-23 is a 22.5kD globular protein containing 228aa.
Catalog #149593
SourceRecombinant protein corresponding to human FGF-23, expressed in E.coli.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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