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You are here:Home » Growth Factors, Cytokines » Growth Factors-BMP » BMP11, Recombinant, Human (Growth/Differentiation Factor 11, GDF-11, Bone Morphogenetic Protein 11, BMP-11, GDF11)

BMP11, Recombinant, Human (Growth/Differentiation Factor 11, GDF-11, Bone Morphogenetic
Protein 11, BMP-11, GDF11)

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Specifications

GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their aa sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25kD disulfide-linked homodimer containing two 109aa polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% aa sequence identity.
Catalog #149601
SourceRecombinant protein corresponding to human GDF-11, expressed in E.coli.
Biological ActivityThe ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10ug/ml.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceNLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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