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You are here:Home » Growth Factors, Cytokines » Growth Factors-Activin, Inhibin » Activin A, Recombinant, Human (AF, Inhibin Beta-1, FRP, FSH-releasing protein)

Activin A, Recombinant, Human (AF, Inhibin Beta-1, FRP, FSH-releasing protein)

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Specifications

Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26kD disulfide-linked homodimer of two beta A chains, each containing 116aa.
Catalog #149604
SourceRecombinant protein corresponding to human Activin A, expressed in High-5 Insect Cells.
Biological ActivityDetermined by its ability to inhibit the proliferation of murine MPC-11 cells. The ED50 was found to be 2ng/ml
Specific Activity5x10e5units/mg
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceGLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source(BTI-Tn-5B1-4) High-5 Insect Cells
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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