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You are here:Home » Molecular Biology » Growth Factors-Interferon » IFNG, Recombinant, Human (Interferon gamma, IFN-gamma, Immune Interferon)

IFNG, Recombinant, Human (Interferon gamma, IFN-gamma, Immune Interferon)

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Specifications

IFN- is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN- receptors are present in most immune cells, which respond to IFN- signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN- signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN- stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN- species-specific and is biologically active only in human and primate cells. Recombinant human IFN- is a 16.7kD protein containing 143aa.
Catalog #149640
Recombinant protein corresponding to human IFN gamma, expressed in E. coli.
Biological ActivityDetermined in a viral resistance assay, the ED50 was found to be 0.05ng/ml.
Specific Activity2x10e7units/mg
Endotoxin 0.1ng/ug (1EU/ug)
Amino Acid SequenceMQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs Reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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