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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interferon » IFNB1, Recombinant, Human (Interferon beta, IFN-beta, Fibroblast Interferon, IFB, IFNB, MGC96956)

IFNB1, Recombinant, Human (Interferon beta, IFN-beta, Fibroblast Interferon, IFB, IFNB,
MGC96956)

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Specifications

Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNalpha is an acid stable molecule that signals through IFNalpha/betaR, which is also used by IFNbeta. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFNalpha contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFNbeta is an 20kD protein containing 166aa. Due to glycosylation, IFNbeta has an approximate MW of 22.3kD based on SDS-PAGE gel and Mass Spectrometry.
Catalog #149641
SourceRecombinant protein corresponding to human IFN beta, expressed in CHO cells.
Biological ActivityThe biological activity of human IFN-B was based on analysis using the WISH cell line with VSV as the challenge virus.
Specific Activity >5x10e8 units/mg
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceCHO cells
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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