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You are here:Home » Molecular Biology » Growth Factors-TNF » TNFSF18, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 18, Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand, GITRL, hGITRL, TL6, UNQ149/PRO175, MGC138237)

TNFSF18, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 18,
Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand,
GITRL, hGITRL, TL6, UNQ149/PRO175, MGC138237)

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Specifications

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177aa, including a 28aa cytoplasmic region, a 21aa transmembrane domain and a 128aa extracellular domain. Recombinant human soluble AITRL is a 14.3kD protein, containing 126aa corresponding to the extracellular domain of AITRL.
Catalog #149657
SourceRecombinant protein corresponding to human TNFSF18, expressed in E.coli.
Biological ActivityDetermined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1-10ng/ml. Note: Results may vary with PBMC donors.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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