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You are here:Home » Molecular Biology » Growth Factors-TNF » TNFRSF14, Fc, Recombinant, Human (HVEM, TR2, Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpes virus Entry Mediator A, HveA, Tumor Necrosis Factor Receptor-like 2, CD270, HVEA, UNQ329/PRO509)

TNFRSF14, Fc, Recombinant, Human (HVEM, TR2, Tumor Necrosis Factor Receptor Superfamily
Member 14, Herpes Virus Entry Mediator A, Herpes virus Entry Mediator A, HveA, Tumor
Necrosis Factor Receptor-like 2, CD270, HVEA, UNQ329/PRO509)

Pricing

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Specifications

HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. Recombinant human HVEM-Fc Chimera is a 376aa fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.
Catalog #149660
SourceRecombinant protein corresponding to human HVEM-Fc, expressed in Hi-5 Insect cells.
Biological ActivityDetermined by its ability to neutralize 0.25ng/ml of hTNFB induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9g/ml of HVEM-Fc.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceLPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceHi-5 Insect cells
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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