Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » Growth Factors-TNF » TNFSF4, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 4, Glycoprotein Gp34, OX40 Ligand, OX40L, TAX Transcriptionally-activated Glycoprotein 1, CD252, TXGP1)

TNFSF4, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 4,
Glycoprotein Gp34, OX40 Ligand, OX40L, TAX Transcriptionally-activated Glycoprotein 1,
CD252, TXGP1)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFN . OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between “friend vs. foe” during activation; a mechanism typically termed immuno-tolerance. Recombinant OX40L is a glycosylated 133aa protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5-25kD on SDS-PAGE.
Catalog #149661
SourceRecombinant protein corresponding to human OX40 Ligand, expressed in Hi-5 Insect cells.
Biological ActivityDetermined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100ng/ml. Note: Results may vary with PBMC donors.
Endotoxin<0.1ng/ug (1EU/ug)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceHi-5 Insect cells
Purity~97% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links