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You are here:Home » Molecular Biology » Growth Factors-IGF » IGFBP2, Recombinant, Human (Insulin-like Growth Factor-binding Protein 2, IBP-2, IGF-binding Protein 2, IGFBP-2, BP2, IBP2)

IGFBP2, Recombinant, Human (Insulin-like Growth Factor-binding Protein 2, IBP-2,
IGF-binding Protein 2, IGFBP-2, BP2, IBP2)

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Specifications

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5kD protein consisting of 289aa including the IGF-BP domain and thyroglobulin type-I domain.
Catalog #149663
SourceRecombinant protein corresponding to human IGF-BP2.
Biological ActivityDetermined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceEVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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