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You are here:Home » Growth Factors, Cytokines » Growth Factors-IGF » IGFBP7, Recombinant, Human (Insulin-like Growth Factor-binding Protein 7, IBP-7, IGF-binding Protein 7, IGFBP-7, IGFBP-rP1, TAF, MAC25 Protein, PGI2-stimulating Factor, Prostacyclin-stimulating Factor, Tumor-derived Adhesion Factor, TAF, MAC25, PSF)

IGFBP7, Recombinant, Human (Insulin-like Growth Factor-binding Protein 7, IBP-7,
IGF-binding Protein 7, IGFBP-7, IGFBP-rP1, TAF, MAC25 Protein, PGI2-stimulating Factor,
Prostacyclin-stimulating Factor, Tumor-derived Adhesion Factor, TAF, MAC25, PSF)

Pricing

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Specifications

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Recombinant human IGF-BP7 is a 26.4kD protein consisting of 257aa.
Catalog #149665
SourceRecombinant protein corresponding to human IGF-BP7, expressed in E.coli.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMSSSDTCGPC EPASCPPLPP LGCLLGETRD ACGCCPMCAR GEGEPCGGGG AGRGYCAPGM ECVKSRKRRK GKAGAAAGGP GVSGVCVCKS RYPVCGSDGT TYPSGCQLRA ASQRAESRGE KAITQVSKGT CEQGPSIVTP PKDIWNVTGA QVYLSCEVIG IPTPVLIWNK VKRGHYGVQR TELLPGDRDN LAIQTRGGPE KHEVTGWVLV SPLSKEDAGE YECHASNSQG QASASAKITV VDALHEIPVK KGEGAEL
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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