Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » MB-Obesity Proteins » Acrp30, Recombinant, Human (30kD Adipocyte Complement-related Protein, ACDC, Adipocyte C1q and Collagen Domain Containing Protein, Adiponectin, ADPN, ADIPOQ, Adipose Most Abundant Gene Transcript 1 Protein, ADIPQTL1, APM1, apM-1, Gelatin-binding Protein,

Acrp30, Recombinant, Human (30kD Adipocyte Complement-related Protein, ACDC, Adipocyte C1q
and Collagen Domain Containing Protein, Adiponectin, ADPN, ADIPOQ, Adipose Most Abundant
Gene Transcript 1 Protein, ADIPQTL1, APM1, apM-1, Gelatin-binding Protein,

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Adiponectin is an adipose-derived secreted protein containing 226aa. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-alpha and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing aa Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35kD by SDS PAGE analysis under reducing conditions.
Catalog #149668
SourceRecombinant protein corresponding to human Adiponectin, expressed in Hi-5 Insect cells.
Biological ActivityDetermined by a cytotoxic assay using M1 cells. The ED50 for this effect is 3-6g/ml.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceRGHHHHHHHH ETTTQGPGVL LPLPKGACTG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFYCNIPGLY YFSYHITVYM KDVKVSLFKK DKAVLFTYDQ YQEKNVDQAS GSVLLHLEVG DQVWLQVYGD GDHNGLYADN VNDSTFTGFL LYHDTN
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceHi-5 Insect cells
Purity~97% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links