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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Ctf2, Recombinant, Mouse (Cardiotrophin-2, CT-2, Neuropoietin, Np, Gm494, LOC244218)

Ctf2, Recombinant, Mouse (Cardiotrophin-2, CT-2, Neuropoietin, Np, Gm494, LOC244218)

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Specifications

Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway. Recombinant mouse Neuropoietin is a 19.8kD protein containing 183aa.
Catalog #149703
SourceRecombinant protein corresponding to mouse Neuropoietin, expressed in E.coli.
Biological ActivityDetermined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The ED50 was found to be 0.5-0.8ug/ml.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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