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You are here:Home » Molecular Biology » Growth Factors-M-CSF » Csf1, Recombinant, Rat (Macrophage Colony-stimulating Factor 1, CSF-1, MCSF, Csfm)

Csf1, Recombinant, Rat (Macrophage Colony-stimulating Factor 1, CSF-1, MCSF, Csfm)

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Specifications

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant rat M-CSF is a 18.1kD homodimeric protein containing two 155aa polypeptide subunits.
Catalog #149722
SourceRecombinant protein corresponding to rat M-CSF, expressed in E.coli.
Biological ActivityDetermined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells. The ED50 was found to be <5ng/ml
Specific Activity>1x10e5 units/mg
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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