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You are here:Home » Molecular Biology » Growth Factors-VEGF » VEGF165, Recombinant, Rat (Vascular Endothelial Growth Factor A Isoform 165A, VEGF 165, VEGF165, VEGF165A, VEGFA)

VEGF165, Recombinant, Rat (Vascular Endothelial Growth Factor A Isoform 165A, VEGF 165,
VEGF165, VEGF165A, VEGFA)

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Specifications

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant rat VEGF is a 38.5kD disulfide-linked homodimeric protein consisting of two 165aa polypeptide chains.
Catalog #149725
SourceRecombinant protein corresponding to rat VEGF165, expressed in E.coli.
Biological ActivityDetermined by the dose-dependent stimulation of the proliferation of Human umbilical vein endothelial cells (HUVEC). The expected ED50 is 4-8ng/ml.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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