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You are here:Home » Molecular Biology » Growth Factors-Neurotrophins » Neuritin, Recombinant, Human (NRN1, NRN, dJ380B8.2, MGC44811)

Neuritin, Recombinant, Human (NRN1, NRN, dJ380B8.2, MGC44811)

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Specifications

Neuritin is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3, and other neural stimulators. It is expressed primarily in postmitotic-differentiating neurons of the developing nervous system and in neuronal structures related to synaptic plasticity in the adult nervous system. Neuritin acts as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation. Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.7kD polypeptide monomers, each containing 88aa.
Catalog #149735
SourceRecombinant protein corresponding to human Neuritin, expressed in E.coli.
Biological ActivityDetermined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20-30ng/ml.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMAGKCDAVFK GFSDCLLKLG DSMANYPQGL DDKTNIKTVC TYWEDFHSCT VTALTDCQEG AKDMWDKLRK ESKNLNIQGS LFELCGSGN
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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