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You are here:Home » Growth Factors, Cytokines » Growth Factors-BDNF » BDNF, Recombinant, Human (Brain-derived Neurotrophic Factor, Abrineurin, OCD1)

BDNF, Recombinant, Human (Brain-derived Neurotrophic Factor, Abrineurin, OCD1)

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Specifications

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247aa polypeptide precursor, which also contains a signal sequence of 18aa residue and a propeptide of 110aa. Recombinant human BDNF is a 27kD homodimer of two 119aa subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical. Manufactured using all non-animal reagents.
Catalog #149740
SourceRecombinant protein corresponding to human BDNF, expressed in E.coli.
Biological ActivityDetermined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1ug/ml.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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