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You are here:Home » Growth Factors, Cytokines » Growth Factors-BMP » BMP3, Recombinant, Human (Bone Morphogenetic Protein 3, BMP-3, Bone Morphogenetic Protein 3A, BMP-3A, Osteogenin, BMP3A)

BMP3, Recombinant, Human (Bone Morphogenetic Protein 3, BMP-3, Bone Morphogenetic Protein
3A, BMP-3A, Osteogenin, BMP3A)

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Specifications

TGF-B family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472aa BMP-3 precursor protein
Catalog #149741
SourceRecombinant protein corresponding to human BMP-3, expressed in HEK293 cells.
Biological ActivityDetermined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC R
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceHEK293 cells
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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