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You are here:Home » Growth Factors, Cytokines » Growth Factors-TNF » DR6, Extracellular Domain, Recombinant, Human, aa42-349, His-tag (Death Receptor 6, BM018, MGC31965, TNFR Related Death Receptor 6, Tumor Necrosis Factor Receptor Superfamily Member 21, Tumor Necrosis Factor Receptor Superfamily Member 21 Precursor, TNFRS

DR6, Extracellular Domain, Recombinant, Human, aa42-349, His-tag (Death Receptor 6, BM018,
MGC31965, TNFR Related Death Receptor 6, Tumor Necrosis Factor Receptor Superfamily Member
21, Tumor Necrosis Factor Receptor Superfamily Member 21 Precursor, TNFRS

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Specifications

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines. Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning.
Catalog #149783
SourceRecombinant protein corresponding to human DR6 Extracellular Domain, fused to His-tag at C-terminal expressed in E.coli.
Molecular Weight~36kD
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityAliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight~36kD
SourceE. coli
Purity~95%
ConcentrationAs reported
FormSupplied as a liquid in 1X PBS,10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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