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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -CDKN2A (Cyclin-dependent Kinase Inhibitor 2A, Isoforms 1/2/3, Cyclin-dependent Kinase 4 Inhibitor A, CDK4I, Multiple Tumor Suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2, MTS1)

Anti -CDKN2A (Cyclin-dependent Kinase Inhibitor 2A, Isoforms 1/2/3, Cyclin-dependent
Kinase 4 Inhibitor A, CDK4I, Multiple Tumor Suppressor 1, MTS-1, p16-INK4a, p16-INK4,
p16INK4A, CDKN2, MTS1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH IF
The CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. Conversely, transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines, suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas. CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6. CDKN2A is expressed as at least three distinct isoforms.
Catalog #149901
ApplicationsSuitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse Colon Tissue Lysate and Human Colon Tissue Lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 18aa from near the N-terminus of human CDKN2A.
SpecificityRecognizes human CDKN2A. Species Crossreactivity: mouse and rat..
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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