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You are here:Home » Antibodies » Abs to Enzymes, Acetyltransferase » Anti -CHAT (Choline O-acetyltransferase, CHOACTase, ChAT, Choline Acetylase, CMS1A, CMS1A2)

Anti -CHAT (Choline O-acetyltransferase, CHOACTase, ChAT, Choline Acetylase, CMS1A,
CMS1A2)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Catalog #150024
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.03-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Placenta Lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 14aa from near the C-terminus of ChAT. Species sequence homology: canine, porcine and bovine.
SpecificityRecognizes human ChAT.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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