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You are here:Home » Antibodies » Abs to Sirtuins » Anti -SIRT3 (Sirtuin 3, hSIRT3, NAD-dependent Protein Deacetylase Sirtuin-3, Mitochondrial, Regulatory Protein SIR2 Homolog 3, SIR2-like Protein 3, SIR2L3)

Anti -SIRT3 (Sirtuin 3, hSIRT3, NAD-dependent Protein Deacetylase Sirtuin-3,
Mitochondrial, Regulatory Protein SIR2 Homolog 3, SIR2-like Protein 3, SIR2L3)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence, lifespan extension and several age-related diseases. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death.
Catalog #150972
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:128,000
Western Blot: 0.1-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Liver Tissue Lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 12aa from near the C-terminus of SIRT3.
SpecificityRecognizes human SIRT3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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