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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -AMIGO-1 (Amphoterin-induced protein 1, Alivin-2, Ali2, AMIGO and KIAA1163)

Anti -AMIGO-1 (Amphoterin-induced protein 1, Alivin-2, Ali2, AMIGO and KIAA1163)

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Specifications

Clone Host Grade Applications
Mouse Affinity Purified B IH IC
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. They can form complexes with each other, but can also self-bind. AMIGO1, also designated Alivin2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin3) plays a role in hemophilic and/or heterophilic cell-cell interaction and signal transduction.
Catalog #167573
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.
Recommended Dilution1ug/ml was sufficient for detection of AMIGO-1 in 20ug of rat brain membrane lysate and assayed by Western Blot using goat anti-mouse IgG:HRP as the secondary antibody.
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type
Concentration~1mg/ml
FormSupplied as a liquid in PBS pH7.4, 50% glycerol.
SpecificityRecognizes human AMIGO-1. Species Crossreactivity: Mouse, Human, Rat. Detects 60-80kD depending on maturity/glycosylation
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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