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You are here:Home » Antibodies » Abs to RNA Processing » Anti -Dicer (Dicer1, DCR, DCR-1, Double-strand-specific ribonuclease, Helicase with RNase motif, HERNA, Helicase MOI and KIAA0928)

Anti -Dicer (Dicer1, DCR, DCR-1, Double-strand-specific ribonuclease, Helicase with RNase
motif, HERNA, Helicase MOI and KIAA0928)

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Specifications

Clone Host Grade Applications
Mouse Affinity Purified B IC
Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs) (1). After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha (2), pre-miRNAs are transported to the cytoplasm
and further processed by Dicer to produce 22-nucleotide mature miRNAs (3). The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA (3)
Catalog #167583
ApplicationsWestern Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution1ug/ml was sufficient for detection of Dicer in 20ug of rat brain lysate by Western Blot using Goat anti-mouse IgG:HRP as the secondary antibody.
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type
Concentration~1mg/ml
FormSupplied as a liquid in PBS pH7.4, 50% glycerol.
SpecificityRecognizes mouse Dicer. Species Crossreactivity: Mouse, Rat, Human. Detects ~215kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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