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You are here:Home » Biochemicals » Biochem-Inflammation » Ebselen (2-Phenyl-1,2-benzisoselenazol-3-(2H)-one)

Ebselen (2-Phenyl-1,2-benzisoselenazol-3-(2H)-one)

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Specifications

An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a  histone-lysine demethylase (HKDM) inhibitor.
Catalog #167813
Solubility~5mg/ml (DMSO)
Molecular Weight~274.18
Biological ActivityInhibits JARID1B protein with an IC of 5.17um.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number60940-34-3
Molecular FormulaC13H9NOSe
Molecular Weight~274.18
PurityHighly Purified (~99%)
FormSupplied as a white to off-white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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