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You are here:Home » Growth Factors, Cytokines » Growth Factors-IGF » IGF-BP3, Recombinant, Human (Human IGF-BP3, IGF-BP3, IGFBP3, h-IGF-BP3, rh-IGF-BP3, recombinant human IGF-BP1, recombinant IGF-BP1, IGF)

IGF-BP3, Recombinant, Human (Human IGF-BP3, IGF-BP3, IGFBP3, h-IGF-BP3, rh-IGF-BP3,
recombinant human IGF-BP1, recombinant IGF-BP1, IGF)

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Specifications

Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9kD cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8kD protein consisting of 264aa residues.
Catalog #167878
SourceRecombinant corresponding to human IGF BP3 expressed in E.coli.
Molecular Weight~29kD
Biological ActivityThe ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ~0.2mg/ml, in the presence of 15ng/ml of human IGF-II.
Endotoxin~0.1ng/ul
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~29kD
SourceE.coli
Purity~98% (HPLC, SDS-PAGE)
FormSupplied as lyophilized powder in 20mM HCl. Reconstitute with dH2O to 0.1-1.0mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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