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You are here:Home » Biochemicals » Biochem-Tyrosine Kinase Inhibitors » Imatinib, Free base

Imatinib, Free base


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An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC50=0.5nm), phosphorylation of a fusion protein (IC50=30nm), and viability of BaF3 cells expressing Rhe-PDGFRa in the absence of IL-3 (IC50 =0.17nm).
Catalog #167887
SolubilityDMSO (25mg/ml) EtOH (5mg/ml)
Molecular Weight~493.6D
Storage and stabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight~493.6D
Purity~99% (HPLC)
FormSupplied as an off white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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