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You are here:Home » Antibodies » Abs to Fanconi Proteins » Anti -FANCC (bA80I15.1, FA 3, FA3, FAC, FACC, Fanconi anemia complementation group C)

Anti -FANCC (bA80I15.1, FA 3, FA3, FAC, FACC, Fanconi anemia complementation group C)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
FANCC (also called Protein FACC or Fanconi anemia group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCC belongs to the multi-subunit Fanconi anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is ubiquitously expressed. Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations.
Catalog #168173
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:20,000-1:80,000
Western Blot: 1:1000-1:3000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa96-112 from human FANCC.
SpecificityRecognizes human FANCC. Species Crossreactivity: chimpanzee.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesbA80I15.1 antibody, FA 3 antibody, FA3 antibody, FAC antibody, FACC antibody, Fanconi anemia complementation group C antibody


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