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You are here:Home » Antibodies » Abs to Protein Kinases, Ribosomal » Anti -P70 S6 Kinase (p70S6Kb, Ribosomal protein S6 kinase 70kD, polypeptide 2, Ribosomal protein S6 kinase beta 2)

Anti -P70 S6 Kinase (p70S6Kb, Ribosomal protein S6 kinase 70kD, polypeptide 2, Ribosomal
protein S6 kinase beta 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP
The protein p70 S6 kinase is critical for cell cycle progression and cell survival. In response to mitogen stimulation, p70 S6 kinase activation up-regulates ribosomal biosynthesis and enhances the translational capacity. p70S6K phosphorylates the S6 protein of the 40S subunit of the ribosome. This kinase was first characterized as an insulin/mitogen-activated protein kinase, whose major known substrate is the 40S ribosomal subunit protein S6. p70S6K is activated by diverse stimuli through multi-site phosphorylation at positions such as Thr-252 and Ser-434. In Alzheimer's Disease, p70S6K activation is associated with PHF-tau (hyperphosphorylated tau) accumulation. In non-neuronal cells, p70S6K has been shown to regulate actin polymerization.
Catalog #168414
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionELISA: 1:5000
Western Blot: 1:1000
Immunoprecipitation: 5ug/mg
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M tris chloride, 0.5M sodium chloride, pH 8.0, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human p70S6K at C-terminal.
SpecificityRecognizes human P70 S6 Kinase.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesp70S6Kb antibody, Ribosomal protein S6 kinase 70kDa, polypeptide 2 antibody, Ribosomal protein S6 kinase beta 2 antibody


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