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You are here:Home » Antibodies » Abs to Chromogranin » Anti -Chromogranin A

Anti -Chromogranin A

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH IF
Neurons and neuroendocrine cells contain membrane-delimited pools of peptide hormones, biogenic amines, and neurotransmitters with a characteristic electron-dense appearance. These vesicles, which are present throughout the neuroendocrine system and in a variety of neurons, store and release chromogranins and secretogranins, a unique group of acidic, soluble secretory proteins. Chromogranin A, a protein of 439 amino acids which is encoded on chromosome 14, and an apparent molecular weight of 68kD, is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors, including small cell lung carcinoma.
Catalog #168972
ApplicationsImmunohistochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:10. With the ABC method the dilution can be 5-10x higher. Dilute immediately before use with PBS or TRIS-HCl pH 7,0.
Optimal dilutions to be determined by the researcher.
HybridomaNS1 myeloma cells with spleen cells from Balb/c mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoLK2H10
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.09% sodium azide.
PuritySupernant
ImmunogenHuman pheochromocytoma
SpecificityRecognizes human Chromogranin A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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