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You are here:Home » Growth Factors, Cytokines » Growth Factors-Inhibin » Activin A, Recombinant, Human, His-tag (Inhibin Beta A, EDF, FRP)

Activin A, Recombinant, Human, His-tag (Inhibin Beta A, EDF, FRP)

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Specifications

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Catalog #169229
SourceRecombinant protein corresponding to human ACTIVIN A expressed in Nicotiana benthamiana.
Molecular Weight~27.4, 13.7kD
Endotoxin<0.04EU/ug
Biological ActivityThe biological activity of ACTIVIN A is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation ( [3H]thymidine incorporation). ED50 5ng/ml.
AA SequenceHHHHHHGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~27.4, 13.7kD
SourceNicotiana benthamiana
Purity~97% (SDS-PAGE)
ConcentrationAs reported
FormSupplied as a lyophilized powder in 0.05M Tris-HCl, pH 7.4. Reconstitute in sterile H2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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