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You are here:Home » Molecular Biology » Growth Factors-BMP » BMP4, Recombinant, Human, aa292-408 (Bone Morphogenetic Protein 4, BMP2B, BMP2B1, MCOPS6, ZYME)

BMP4, Recombinant, Human, aa292-408 (Bone Morphogenetic Protein 4, BMP2B, BMP2B1, MCOPS6,
ZYME)

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Specifications

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Catalog #169256
SourceRecombinant protein corresponding to aa292-408 from human BMP4 expressed in E. coli (Accession# P12644).
Molecular Weight~13kD
Endotoxin< 0.1ng/ug (1EU/ug)
Biological ActivityThe ED50 was determined by its ability to induce alkaline phosphatase production in mouse ATDC5 chondrogenic and was found to be in the range of 0.1-0.2ug/ml.
AA SequenceSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~13kD
SourceE. coli
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder in 20mM Na2CO3, pH 9. Reconstitute in ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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