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You are here:Home » Molecular Biology » Growth Factors-BMP » BMP5, Recombinant, Human (Bone Morphogenetic Protein 5, MGC34244)

BMP5, Recombinant, Human (Bone Morphogenetic Protein 5, MGC34244)

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Specifications

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
Catalog #169257
SourceRecombinant protein corresponding to human BMP5 expressed in E. coli (Accession# P22003).
Molecular Weight~31kD
Endotoxin<0.1ng/ug
Biological ActivityThe ED50 as determined by the dose-dependent induction of alkaline phosphatase production with ATDC5 chondrogenic cells is 0.3-3ug/ml.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~31kD
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder. Reconstitute in sterile H2O, BSA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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