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You are here:Home » Molecular Biology » Growth Factors-CCL » CCL2, Recombinant, Human, aa24-99 (C-C motif Chemokine 2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF)

CCL2, Recombinant, Human, aa24-99 (C-C motif Chemokine 2, GDCF-2, HC11, HSMCR30, MCAF,
MCP-1, MCP1, MGC9434, SCYA2, SMC-CF)

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Specifications

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Catalog #169302
SourceRecombinant protein corresponding to aa24-99 from human CCL2 expressed in E. coli (Accession# P13500).
Molecular Weight~9kD
Endotoxin<0.1ng/ug (1EU/ug)
Biological ActivityDetermined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/ml.
AA SequenceQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~9kD
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder in 0.02M Tris-HCl, pH 7.5. Reconstitute in ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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