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You are here:Home » Molecular Biology » Growth Factors-GM-CSF » CSF2, Recombinant, Human, aa18-144 (Granulocyte-macrophage Colony Stimulating Factor 2, GMCSF, MGC131935, MGC138897)

CSF2, Recombinant, Human, aa18-144 (Granulocyte-macrophage Colony Stimulating Factor 2,
GMCSF, MGC131935, MGC138897)

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Specifications

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
Catalog #169355
SourceRecombinant protein corresponding to aa18-144 from human CSF2 expressed in E. coli (Accession# NP_000749).
Molecular Weight~14.6kD
Endotoxin<1.0EU/1ugram of protein (LAL method)
Biological ActivityThe ED50 for this effect is <0.18ng/ml. Measured in a cell proliferation assay using TF1 human erythroleukemic cells.
AA SequenceMAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~14.6kD
SourceE. coli
Purity~95% (SDS-PAGE)
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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