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You are here:Home » Molecular Biology » Growth Factors-CXCL » CXCL1, Recombinant, Human, aa35-107 (C-X-C Motif Chemokine 1, alpha Melanoma Growth Stimulating Activity, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1)

CXCL1, Recombinant, Human, aa35-107 (C-X-C Motif Chemokine 1, alpha Melanoma Growth
Stimulating Activity, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1)

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Specifications

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils, while non-ELR types are chemotactic for lymphocytes.
Catalog #169371
SourceRecombinant protein corresponding to aa35-107 from human CXCL1 expressed in E. coli (Accession# P09341).
Molecular Weight~8kD
Endotoxin<0.1ng/ug (1EU/ug)
Biological ActivityDetermined by the ability to chemoattract human neutrophils using a concentration range of 10.0-50.0ng/ml.
AA SequenceASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~8kD
SourceE. coli
Purity~97% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder in 40mM NaCl, 10mM PBS, pH 7.0. Reconstitute in ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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