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You are here:Home » Growth Factors, Cytokines » Growth Factors-CXCL » CXCL12, Recombinant, Mouse, aa22-89 (C-X-C Motif Chemokine 12, AI174028, PBSF, PBSF/SDF-1, SDF-1, Scyb12, Sdf1, Sdf1a, Sdf1b, TLSF, TLSF-a, TLSF-b, TPAR1)

CXCL12, Recombinant, Mouse, aa22-89 (C-X-C Motif Chemokine 12, AI174028, PBSF, PBSF/SDF-1,
SDF-1, Scyb12, Sdf1, Sdf1a, Sdf1b, TLSF, TLSF-a, TLSF-b, TPAR1)

Pricing

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Specifications

SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12).SDF-1 is produced in two forms, SDF-1a/CXCL12a and SDF-1b/CXCL12b, by alternate splicing of the same gene. SDF-1b is synthesized as a 93 amino acid (aa) precursor that contains a 21aa signal sequence and a 72aa mature region. The mature molecule exhibits a typical three antiparallel -strand chemokine-like fold. There are no potential N-linked glycosylation sites. N-terminal aa s 1-8 form a receptor binding site, while aas 1 and 2 (Lys-Pro) are involved in receptor activation. The C-terminus is likely associated with heparin binding. SDF-1b circulates and undergoes proteolytic processing. SDF-1b are reported to be a monomers at neutral pH and physiologic ionic strength.
Catalog #169380
SourceRecombinant protein corresponding to aa22-89 from mouse Cxcl12 expressed in E. coli (Accession# NP_001012495.1).
Endotoxin<0.01ng/mg or 0.1EU/mg.
Specific ActivityDetermined by its ability to chemoattract human monocytes at 50.0-100.0ng/ml.
AA SequenceKPVSLSYRCPCRFFESHIARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (RP-HPLC, reducing and non-reducing SDS-PAGE)
ConcentrationAs reported
FormSupplied as a lyophilized powder. Reconstitute in sterile H2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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