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You are here:Home » Molecular Biology » Growth Factors-FGF » FGF18, Recombinant, Human (Fibroblast Growth Factor 18, FGF-18, ZFGF5)

FGF18, Recombinant, Human (Fibroblast Growth Factor 18, FGF-18, ZFGF5)

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Specifications

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
Catalog #169436
SourceRecombinant protein corresponding to human FGF18 expressed in E. coli (Accession# O76093).
Molecular Weight~21.2kD
Endotoxin<0.1ng/ug
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is <0.5ng/ml.
Specific Activity>2x106units/mg
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~21.2kD
SourceE. coli
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder in 10mM Tris pH 8.0. Reconstitute in 5mM Tris.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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