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You are here:Home » Molecular Biology » Growth Factors-FGF » FGF2, Recombinant, Human, aa143-288 (Fibroblast Growth Factor, FGF)

FGF2, Recombinant, Human, aa143-288 (Fibroblast Growth Factor, FGF)


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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Catalog #169441
SourceRecombinant protein corresponding to aa143-288 from human FGF2 expressed in E. coli (Accession# NP_001997.5).
Molecular Weight~16.5kD
Endotoxin Level<1.0EU/1ug (LAL method)
Biological ActivityThe ED50 for this effect is 0.1-1.5ng/ml. Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~16.5kD
SourceE. coli
Purity~95% (SDS-PAGE)
FormSupplied as a liquid in 50mM Tris, pH 8.0.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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