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You are here:Home » Molecular Biology » Growth Factors-GDF » GDF11, Recombinant, Human (Growth Differentiation Factor 11, BMP-11, BMP11)

GDF11, Recombinant, Human (Growth Differentiation Factor 11, BMP-11, BMP11)

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Specifications

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
Catalog #169473
SourceRecombinant protein corresponding to human GDF11 expressed in E. coli (Accession# O95390).
Molecular Weight~32.6kD
Endotoxin<0.1ng/ug
Biological ActivityThe protein is biologically active as determined by its ability to induce alkaline phosphatase production by C2C12 cells. The ED50 is in the range of 0.4-4ug/ml.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~32.6kD
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder in 10mM sodium citrate, pH 3.5. Reconstitute in sterile H2O, BSA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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