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You are here:Home » Biochemicals » Biochem-Inflammation » 1400W Dihydrochloride

1400W Dihydrochloride


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Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd 7nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with K values of 2 and 50uM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.
Catalog #169589
SolubilityWater (100mM)
PubChem CID 2733515
MDL Number: MFCD03428622
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number214358-33-5
Molecular FormulaC10H25N3.2HCL
Molecular Weight250.17
Purity~98% by NMR
FormSupplied as a white to off-white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesN-(3-(Aminomethyl)benzyl)acetamidine 2HCl

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