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You are here:Home » Growth Factors, Cytokines » Growth Factors-Follistatin » Follistatin, Recombinant, Mouse (FS, activin-binding protein, FSH-suppressing protein, FSP)

Follistatin, Recombinant, Mouse (FS, activin-binding protein, FSH-suppressing protein,
FSP)

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Specifications

Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-beta family members (activin, BMPs, myostatin, GDF-11 and TGF-beta 1). Mechanistically, follistatin works as an antagonist by complexing with TGF-beta family members to prevent them from interacting with their signaling receptors. Recombinant mouse follistatin is a nonglycosylated protein, containing 289 amino acids, with a molecular weight of 31.6kD.
Catalog #169974
SourceRecombinant protein corresponding to 289aa from mouse Follistatin, expressed in E. coli.
Molecular Weight~31.6kD
Biological ActivityThe activity is determined by the dose-dependent neutralization of 7.5ng/ml human Activin A. Complete neutralization is typically reached at <0.3ug/ml.
Endotoxin<0.1EU/ug purified protein
AA SequenceMGNCWLRQAK NGRCQVLTKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRM NKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPE PASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~31.6kD
SourceE. coli
Purity~90% (SDS-PAGE, HPLC)
Concentration~0.1mg/ml after reconstitution
FormSupplied as a lyophilized powder in 10mM Na2PO4, 50mM NaCl, pH 7.5. Reconstitute with sterile dH2O to a concentration of 0.1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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