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You are here:Home » Biochemicals » Biochem-Antibiotics » Heptelidic Acid (Koningic acid, Avocettin, FO-4443, BRN 5091359)

Heptelidic Acid (Koningic acid, Avocettin, FO-4443, BRN 5091359)


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A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.
Catalog #169990
SolubilityDMSO or EtOH
Molecular Weight~280.32
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number74310-84-2
Molecular FormulaC15H20O5
Molecular Weight~280.32
Purity~95% (HPLC)
ConcentrationNot determined
FormSupplied as a white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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