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You are here:Home » Antibodies » Abs to Glycols » Anti -Polyethylene Glycol (PEG)

Anti -Polyethylene Glycol (PEG)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E B
Polyethylene Glycol (PEG) is a polymer of ethylene oxide available in size variants from 400D to 40kD. It is nonionic, nontoxic, biocompatible, strong, and hydrophilic and has a large exclusion volume in aqueous solution. PEG has a number of industrial and biomedical applications. The modification of a biopharmaceutical with PEG increases its hydrodynamic radius, reduces immunogenicity and proteolytic cleavage. In particular, therapeutic proteins are conjugated with PEG to slow down their clearance from circulation and improve bioavailability. PEG antibodies can be a vital tool for propelling therapeutics to market by serving as a positive control anti-drug antibody, measuring clearance of a drug, or simply as a QA release confirming PEGylation.
Catalog #170042
ApplicationsSuitable for use in ELISA, Western Blot and Positive Controls for Drug Detection Assays. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No14e16
HostRat
Concentration~1mg/ml
FormSupplied as a liquid in TBS, pH 9.0.
PurityPurified by CHT chromatography from in vitro production.
ImmunogenPEG-KLH
SpecificityRecognizes PEG. Reacts with PEGylated proteins such as PEG-GCSF, PEG-Erythropoietin, and PEG-Interferon, but does not react to unmodified form of the same proteins. Species Crossreactivity: all
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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