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You are here:Home » Molecular Biology » Growth Factors-NGF » ProNGF, Recombinant, Human (Beta-nerve growth factor Beta-NGF)

ProNGF, Recombinant, Human (Beta-nerve growth factor Beta-NGF)


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The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystine knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
Catalog #170056
SourceRecombinant protein corresponding to human ProNGF, expressed in E. coli.
Molecular Weight~25kD
Endotoxin<0.1ng/ug (1IEU/ug)
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~25kD
SourceE. coli
Purity~95% (SDS-PAGE, HPLC)
Concentration~1mg/ml after reconstitution
FormSupplied as a lyophilized powder in 20mM PB, pH 7.2, 250mM NaCl. Reconstitute with 1x PBS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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