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You are here:Home » Antibodies » Abs to Serotonin Receptors » Anti -5-HT4 (HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5-HT4 Receptor, 5-hydroxytryptamine 4 Receptor, 5-hydroxytryptamine Receptor 4, Serotonin 5-HT-4a Receptor, Serotonin Receptor 4, Cardiac 5-HT4 Receptor, Serotonin 4 Receptor, Serotonin 5-HT-4 Receptor)

Anti -5-HT4 (HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5-HT4 Receptor, 5-hydroxytryptamine 4 Receptor,
5-hydroxytryptamine Receptor 4, Serotonin 5-HT-4a Receptor, Serotonin Receptor 4, Cardiac
5-HT4 Receptor, Serotonin 4 Receptor, Serotonin 5-HT-4 Receptor)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14aa into the second intracellular loop.
Catalog #170103
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 7-17ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 20aa from the C-terminus of human 5-HT4. Species sequence homology: bat, bovine, canine and rabbit.
SpecificityRecognizes human 5-HT4. Species Crossreactivity: equine, monkey, porcine, gorilla, gibbon
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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