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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -CHRM2 (CHRM2, 7TM Receptor, HM2, M2 Muscarinic Receptor, M2-mAChR, Muscarinic Receptor M2, Muscarinic M2 Receptor)

Anti -CHRM2 (CHRM2, 7TM Receptor, HM2, M2 Muscarinic Receptor, M2-mAChR, Muscarinic
Receptor M2, Muscarinic M2 Receptor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Muscarinic cholinergic receptor 2, an Acetylcholine Receptor, has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women.
Catalog #170305
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 4-8ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 19aa from 3rd cytoplasmic domain of human CHRM2. Species sequence homology: canine, hamster, monkey, porcine and rat.
SpecificityRecognizes human CHRM2. Species Crossreactivity: gibbon, chimpanzee, gorilla and orangutan.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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