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You are here:Home » Antibodies » Abs to Thioredoxin » Anti -ERP44 (ER Protein 44, PDIA10, TXNDC4, KIAA0573)

Anti -ERP44 (ER Protein 44, PDIA10, TXNDC4, KIAA0573)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.
Catalog #170460
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 15-20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 20aa from the internal region of human ERP44. Species sequence homology: zebrafish.
SpecificityRecognizes human ERP44. Species Crossreactivity: chimpanzee, gorilla, orangutan, gibbon, monkey, mouse, rat, bat, bovine, canine, guinea pig, equine, porcine, rabbit, chicken, xenopus
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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