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You are here:Home » Antibodies » Abs to Gangliosides » Anti -GM2A (Ganglioside GM2 activator, GM2 Ganglioside Activator, GM2-AP, SAP-3)

Anti -GM2A (Ganglioside GM2 activator, GM2 Ganglioside Activator, GM2-AP, SAP-3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The protein encoded by this gene is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme, beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. This protein has also been associated with small cell lung carcinoma.
Catalog #170582
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa from the internal region of human GM2A. Species sequence homology: monkey.
SpecificityRecognizes human GM2A. Species Crossreactivity: gibbon, chimpanzee, gorilla and orangutan.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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