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170900 Rabbit Anti-Leukotriene B4 Receptor (LTB4R, BLT, BLT1, BLTR, Blt-1, Chemokine Receptor-like 1, G-Protein-Coupled Receptor 16, GPR16, Leukotriene B4 Receptor, Leukotriene B4 Receptor 1, G-Protein Coupled Receptor 16, LTBR1, p2Y Purinoceptor 7, p2Y7, LTB4-R 1, p2RY7, CMKRL1, LTB4-R1, LTB4R1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q15722
Isotype
IgG
Grade
Affinity Purified
Applications
IHC
Crossreactivity
Eq Hm Hu Mk Mo Rb Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

BLT1 is a Chemoattractant Receptor that binds the potent chemoattractant leukotriene B4 (LTB4) which is involved in defense against infection. Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al., 1997). Although BLT1 shows homology to other P2Y receptors, it does not function as a purinoreceptor ( Yokomizo et al., 1997).

Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (Formalin fixed paraffin embedded): 5-10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to 16aa from 3rd cytoplasmic domain of human Leukotriene B4 Receptor.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Leukotriene B4 Receptor. Species crossreactivity: gibbon, gorilla, hamster, equine, monkey, mouse, rabbit and rat.
References
1. Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Bck M, Bu DX, Brnstrm R, Sheikine Y, Yan ZQ, Hansson GK. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:17501-6. (IHC-Fr; Human) [PubMed:16293697] [PMC:PMC1297663]
USBio References
No references available
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